Heavy metal exposure in children has been associated with a variety of physiological and neurological problems. The goal of this study was to utilize proteomics to enhance the understanding of biochemical interactions responsible for the health problems related to lead and mercury exposure at concentrations well below CDC guidelines. Blood plasma and serum samples from 34 children were depleted of their most abundant proteins using antibody-based affinity columns and analyzed using two different methods, LC-MS/MS and 2-D electrophoresis coupled with MALDI-TOF/MS and tandem mass spectrometry. Apolipoprotein E demonstrated an inverse significant association with lead concentrations (average being one microgram/deciliter) as deduced from LC-MS/MS and 2-D electrophoresis and confirmed by Western blot analysis. This coincides with prior findings that Apolipoprotein E genotype moderates neurobehavioral effects in individuals exposed to lead. Fifteen other proteins were identified by LC-MS/MS as proteins of interest exhibiting expressional differences in the presence of environmental lead and mercury.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935177 | PMC |
| http://dx.doi.org/10.1021/pr100204g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Infants' Exposure to Toxic Trace Elements in Teethers.
Biol Trace Elem Res
January 2025
College of Arts & Sciences, American University of Kuwait, P.O. Box 3323, 13034, Safat, Kuwait.
Infants are particularly vulnerable to exposure to toxic trace elements due to their developmental stage and behaviors such as mouthing and chewing on toys. Chemical exposure to heavy metals in infants' toys is a significant concern as it poses a threat to their health and well-being. Therefore, quality control measures are essential to prevent infants' exposure to potentially harmful metals.
View Article and Find Full Text PDFToxic metal contamination in edible salts and its attributed human health risks: a systematic review and meta-analysis.
Environ Sci Pollut Res Int
January 2025
Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sodium chloride, commonly referred to as table salt, is the most widely utilized seasoning in culinary applications. Nevertheless, the most of oral salts used contain impurities. Arsenic (As), mercury (Hg), cadmium (Cd), and lead (Pb) are the most common impurities found in salt.
View Article and Find Full Text PDFThe content and associated health risk assessment of toxic elements, micro-, and macrominerals in common carp, Wels catfish, and silver carp from the Danube River in Serbia.
Environ Geochem Health
January 2025
Military Health Department, Veterinary Service Centre, Ministry of Defence of Republic of Serbia, Crnotravska 17, 11000, Belgrade, Serbia.
Three fish species (common carp, Wels catfish, and silver carp) were collected from three locations along the Danube River in Serbia, and fish meat was analyzed for the content of toxic elements, micro- and macrominerals. Silver carp had the highest lead (Pb), arsenic (As), and cadmium (Cd) content, while Wels catfish had the highest level of mercury (Hg). Moreover, metal pollution index (MPI) ranged from 0.
View Article and Find Full Text PDFMajor heavy metals and human gut microbiota composition: a systematic review with nutritional approach.
J Health Popul Nutr
January 2025
Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: The human gut microbiota has a critical role in several aspects of host homeostasis, such as immune development, metabolism, nutrition, and defense against pathogens during life. It can be sensitive to xenobiotics including drugs, diet, or even environmental pollutants, especially heavy metals (HMs). The findings of some previous studies are heterogeneous due to the inclusion of various types of study (human, and animal studies) and wide exposures (phthalate, bisphenol A, HMS, etc.
View Article and Find Full Text PDFFrom contamination to detection: The growing threat of heavy metals.
Heliyon
January 2025
Institute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, P.O. Box 74, New Cairo, 11835, Egypt.
Heavy metals like lead, mercury, cadmium, and arsenic are environmental pollutants that accumulate in ecosystems and pose significant health risks to humans and wildlife, primarily through food chain contamination where plants absorb heavy metals, affecting their growth and threatening consumer health. Cognitive and cardiovascular functions are particularly affected by exposure to heavy metals even at low concentrations through the induction of oxidative stress. Various analytical techniques are used in measuring heavy metals in different environmental and biological samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!