Conventional microfluidic devices typically require highly precise pumps or pneumatic control systems, which add considerable cost and the requirement for power. These restrictions have limited the adoption of microfluidic technologies for point-of-care applications. Paper networks provide an extremely low-cost and pumpless alternative to conventional microfluidic devices by generating fluid transport through capillarity. We revisit well-known microfluidic devices for hydrodynamic focusing, sized-based extraction of molecules from complex mixtures, micromixing, and dilution, and demonstrate that paper-based devices can replace their expensive conventional microfluidic counterparts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892122 | PMC |
| http://dx.doi.org/10.1039/c004821f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting Aβ42.
Lab Chip
January 2025
School of Advanced Technology, Xi'an Jiaotong-Liverpool University, Suzhou, 215000, China.
Alzheimer's disease (AD) is the leading cause of dementia worldwide, and the development of early screening methods can address its significant health and social consequences. In this paper, we present a rotary-valve assisted paper-based immunoassay device (RAPID) for early screening of AD, featuring a highly integrated on-chip rotary micro-valve that enables fully automated and efficient detection of the AD biomarker (amyloid beta 42, Aβ42) in artificial plasma. The microfluidic paper-based analytical device (μPAD) of the RAPID pre-stores the required assay reagents on a μPAD and automatically controls the liquid flow through a single valve.
View Article and Find Full Text PDFIn Situ Raman Spectroscopy-Enabled Microfluidic Gel Chromatography for Revealing Real-Time Separation Dynamics of Single-Walled Carbon Nanotubes.
Polymers (Basel)
January 2025
Department of Materials Science and Engineering, Gachon University, Seongnam 13120, Republic of Korea.
Single-walled carbon nanotubes (SWNTs) exhibit distinct electronic properties, categorized as metallic or semiconducting, determined by their chirality. The precise and selective separation of these electronic types is pivotal for advancing nanotechnology applications. While conventional gel chromatography has been widely employed for large-scale separations, its limitations in addressing microscale dynamics and electronic-type differentiation have persisted.
View Article and Find Full Text PDFMicrofluidic-SERS platform with in-situ nanoparticle synthesis for rapid E. coli detection in food.
Food Chem
January 2025
China Light Industry Key Laboratory of Food Intelligent Detection & Processing, School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, United Kingdom. Electronic address:
A microfluidic-surface enhanced Raman spectroscopy (SERS) platform for rapid detection of Escherichia coli in food products is proposed. By implementing a Y-junction serpentine microfluidic channel, we achieved in-situ synthesis of silver nanoparticles (AgNPs), for enhancing SERS signal intensity. The synthesis of AgNPs was guided by specific aptamers bound to the bacterial cell, which facilitated formation of nanoparticles.
View Article and Find Full Text PDFRecent advances in centrifugal microfluidics for point-of-care testing.
Lab Chip
January 2025
The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Point-of-care testing (POCT) holds significant importance in the field of infectious disease prevention and control, as well as personalized precision medicine. The emerging microfluidics, capable of minimal reagent consumption, integration, and a high degree of automation, play a pivotal role in POCT. Centrifugal microfluidics, also termed lab-on-a-disc (LOAD), is a significant subfield of microfluidics that integrates crucial analytical steps onto a single chip, thereby optimizing the process and enabling high-throughput, automated analysis.
View Article and Find Full Text PDFSample-to-answer microfluidic device towards the point-of-need detection of enterotoxin genes in ruminant milk.
Lab Chip
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow, UK.
Milk is commonly screened both for indicators of animal disease and health, but also for foodborne hazards. Included in these analyses is the detection of , that can produce an enterotoxin, causing staphylococcal food poisoning (SFP), which often leads to sudden onset of significant gastrointestinal symptoms in humans. Epidemiological data on SFP are limited, particularly in low- and middle-income countries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!