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New strategies for a sustainable Tc supply to meet increasing medical demands: Promising solutions for current problems.
Front Chem
July 2022
Department of Chemistry, Biochemistry, and Pharmaceutical Sciences (DCBP), Faculty of Science, University of Bern, Bern, Switzerland.
The continuing rapid expansion of Tc diagnostic agents always calls for scaling up Tc production to cover increasing clinical demand. Nevertheless, Tc availability depends mainly on the fission-produced Mo supply. This supply is seriously influenced during renewed emergency periods, such as the past Mo production crisis or the current COVID-19 pandemic.
View Article and Find Full Text PDFClinical Efficacy of Sodium [99mTc] Pertechnetate from Low Specific Activity 99Mo/99mTc Autosolex Generator in Hospital Radiopharmacy Centre.
Nucl Med Rev Cent East Eur
May 2021
Raja Ramana Fellow, Trombay, 400 085 Mumbai, India.
Background: Few nuclear reactors in the world producing high specific activity (HSA) 99Mo using enriched 235U (HEU), are aging and are planned for shut down in the near future. Further, HEU will not be freely available, due to safeguards, and the technology for 99Mo from low-enriched 235U (LEU) is not yet widely accepted since 239Pu contamination in the product is an issue. Production of 99mTc from low specific activity (LSA) 99Mo obtained from 98Mo(n,)99Mo reaction in research reactor and 100Mo(,n)99Mo reaction in accelerator or directly from 100Mo(p,2n)99mTc nuclear reaction in cyclotron, has been explored [1].
View Article and Find Full Text PDFComparison of 99mTc Injected Activity with Prescribed Activity in Four Types of Nuclear Medicine Exams.
Curr Radiopharm
November 2020
Department of Physics, Faculty of Science, University of Gujrat, Hafiz Hayat Campus, Gujrat, 50700, Pakistan.
Background: 99mTc is a radioactive isotope that is obtained by eluting a 99Mo/99mTc generator. (PINSTECH, Islamabad) and used for radionuclide scanning.
Objectives: The objective of this work is to study the uncertainties in 99mTc activity that exist due to time delay between injection preparation and administration to patients, during the process of gamma camera scanning.
Fractionated elution of 99Mo/99mTc generators using calibrated vials.
Nucl Med Commun
September 2018
U1086 INSERM-UCN, 'ANTICIPE'.
Fractionated elution consists in collecting the fractions of an eluate with the highest radioactive concentration. It may be useful to meet the requirements of a subset of clinical radiopharmacy procedures. This study aims to describe and evaluate straightforward procedures allowing to readily perform fractionated elution on dry and wet columns Mo/Tc generators by using calibrated vials.
View Article and Find Full Text PDF[Simplicity or complexity of the radiopharmaceutical production process in the light of optimization of radiation protection of staff - 99mTc vs. 18F].
Med Pr
May 2018
Uniwersytet Łódzki / University of Lodz, Łódź, Poland (Wydział Fizyki i Informatyki Stosowanej, Katedra Fizyki Jądrowej i Bezpieczeństwa Radiacyjnego / Faculty of Physics and Applied Informatics, Department of Nuclear Physics and Radiation Safety).
Background: A radiopharmaceutical is a combination of a non-radioactive compound with a radioactive isotope. Two isotopes: technetium-99m (99mTc) and fluorine-18 (18F) are worth mentioning on the rich list of isotopes which have found numerous medical applications. Their similarity is limited only to the diagnostic area of applicability.
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