Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925441 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2010.07.023 | DOI Listing |
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