AI Article Synopsis
- Pityriasis rubra pilaris (PRP) is a rare skin condition with an unclear cause, often seen in a familial form that typically shows autosomal dominant inheritance.
- The authors describe two cases of PRP occurring in a mother and her son, highlighting the familial aspect of the disease.
- They also discuss the potential effectiveness of etanercept, a medication that has shown promise in treating resistant PRP cases, particularly in the mother of the reported cases.
Article Abstract
Pityriasis rubra pilaris (PRP) is an uncommon dermatosis of unknown etiology. The familial subtype is rare and usually presents as type V PRP. It is generally inherited in an autosomal dominant fashion with variable expression. Other forms of inheritance, such as autosomal recessive and X-linked, have also been reported. The use of etanercept in treating resistant forms of PRP is promising given reports of its success in a few cases. Herein, the authors report two cases of PRP arising in a mother and son and review the rare familial subtype of this disease. In addition, a successful therapeutic trial of etanercept was initiated in the mother based on case reports of its efficacy in other patients with PRP.
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