AI Article Synopsis
- * The symptoms of pneumonia caused by the resistant strain were similar to those caused by the sensitive strain, indicating no obvious clinical differences.
- * Genetic analysis revealed specific mutations in the 23S rRNA gene, leading to high resistance to erythromycin; while common in children, doctors should also consider this resistance in adult patients.
Article Abstract
A macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia. The pneumonia severity score of both patients was mild, and rapid clinical improvement was seen after administration of fluoroquinolone. Clinical features of macrolide-resistant M. pneumoniae pneumonia were identical to those of macrolide-sensitive M. pneumoniae pneumonia. An A-to-G transition at position 2063 and 2064, respectively, in domain V of the 23S rRNA gene was identified. The minimum inhibitory concentration of erythromycin of these isolates was greatly elevated. In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults.
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