Piebaldism is a rare genodermatosis in which depigmented skin areas are unresponsive to topical or light treatment. This article describes the importance of transplant techniques using noncultured melanocytes (minigrafting) in the treatment of piebaldism.
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Cryoblebbing with 5-fluorouracil versus cryoblebbing with melanocyte keratinocyte transplant procedure or cryoblebbing alone in treatment of stable vitiligo.
Arch Dermatol Res
January 2025
Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Both the surgical non-cultured melanocyte-keratinocyte transplant procedure (MKTP) and intradermal injection of 5-Fluorouracil (5-FU) are effective in the treatment of vitiligo. Intrablisters injection of MKTP was done in one study with better results than MKTP application after ablative CO2 laser of the reciepient area. However, intrablister injection of 5-FU was not done before.
View Article and Find Full Text PDFSegmental vitiligo: autoimmune pathogenesis, neuronal mechanisms, and somatic mosaicism.
Int J Dermatol
December 2024
Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Vitiligo is a common depigmentation disorder classified into nonsegmental vitiligo (NSV) and segmental vitiligo (SV). SV accounts for 5-27.9% of patients with vitiligo.
View Article and Find Full Text PDFStem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.
Indian J Med Res
November 2024
Department of Pediatrics, All India Institute of Medical Sciences, Patna, India.
Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy.
View Article and Find Full Text PDFLow Incidence of Cancer Recorded in the Galapagos Archipelago.
Cancer Rep (Hoboken)
December 2024
Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Article Synopsis
- Cancer incidence in the Galapagos Islands was previously unknown, leading to a 2021 task force study involving Ecuadorian and Italian researchers to estimate cancer cases among the local population of over 25,000 residents.
- From 2013 to 2019, 174 new cancer cases were found, with a higher occurrence in females; the prevalent types included prostate and gastric cancers in men and breast and cervical cancers in women, showcasing significant gender differences.
- The age-standardized incidence rates for both genders were notably lower than those in mainland Ecuador and other South American countries, suggesting a need for further research and prevention strategies based on environmental factors.
Recent trends in the treatment of vitiligo using novel drug delivery system.
Int J Pharm
December 2024
Department of Pharmacology, Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh 490024, India.
Vitiligo is a complex dermatological disorder involving the loss of melanocytes, with resultant patches of depigmentation. It affects 1% of the world population, affecting patients' mental health and quality of life. With all the improvement seen, conventional treatment methods-steroids, phototherapy, and immunomodulators-come with the limitations of being less effective, having more side effects, and low compliance.
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