Similar Publications

COVID-19 Vaccine Hesitancy Among Black Women in the US.

JAMA Netw Open

January 2025

Department of Management, Policy, and Community Health, School of Public Health, The University of Texas Health Science Center, Houston.

Importance: COVID-19 vaccine hesitancy among Black women is a critical public health concern, potentially exacerbating existing health disparities and impacting community-wide vaccination efforts.

Objective: To explore the factors associated with COVID-19 vaccine hesitancy among Black women in the US and identify the specific concerns and experiences shaping hesitant attitudes toward vaccination.

Design, Setting, And Participants: Qualitative study using in-depth, semistructured interviews conducted virtually between June and November 2021.

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African Americans (AAs) with end-stage kidney disease (ESKD) experience significant barriers to accessing living donor kidney transplantation (LDKT), largely due to individual and systemic factors, including a lack of trust in healthcare systems resulting from a legacy of and continued experiences with medical racism. This cross-sectional study analyzed survey data from 416 AA patients with ESKD undergoing transplant evaluation in 2019-2023 at two kidney transplant centers in the Southeast United States, examining whether trust (specifically trust in kidney doctors, hospitals, and healthcare) modifies the relationship between attitudes towards LDKT and behavioral intentions to discuss LDKT with family and friends. Multivariable analyses revealed significant interactions.

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Biomarkers.

Alzheimers Dement

December 2024

University of California, Los Angeles Integrative Biology and Physiology (IBP), Los Angeles, CA, USA.

Background: APOE is in linkage disequilibrium with the length of poly-T repeats at the rs10524523 ('523) locus of the TOMM40 gene. APOE-ε3 is associated with short (S) and (VL) variants of '523 in white and Black individuals. In white individuals, APOE-ε4 is associated with the long (L) '523 variant, but is associated with '523-S, '523-L, and '523-VL variants in Black individuals.

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Background: Biomarkers, such as blood p-tau181, p-tau217, and p-tau231, have been created and verified to mirror the pathophysiology of tau and amyloid-β (Aβ) in the brain . Sleep spindles are known to contribute to memory consolidation and generalization and may therefore be a promising biomarker in preclinical Alzheimer's Disease (AD) . The present study investigated the relationship between sleep spindles and p-tau levels in cognitively healthy older African Americans.

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Background: Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD) and disproportionately impacts under-represented groups including Mexican Americans/Hispanics (MAs) and African Americans/Blacks (AAs) compared to non-Hispanic Whites (NHWs). However, it remains unclear how amyloid, tau, and neurodegeneration (AT(N)) AD imaging biomarkers and cognitive functioning differ across diabetic stages including non-diabetes, pre-diabetes, and T2DM in a diverse community-based cohort.

Method: Data were obtained from the well-characterized Health and Aging Brain Study: Health Disparities (HABS-HD) cohort, including MAs (n=612), AAs (n=676), and NHWs (n=725) with clinical, amyloid and tau positron emission tomography (PET), and cortical thickness measures from magnetic resonance imaging (MRI) scans.

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