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Physiological Roles of DNA Double-Strand Breaks.
J Nucleic Acids
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School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0SP, UK.
Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these processes represent an important category of anticancer therapeutics.
View Article and Find Full Text PDFThe double-helix derailed: the story of the BRCA patent.
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Optical detection of thymine dinucleoside monophosphate and its cis-syn photodimer by inorganic nanoparticles.
J Fluoresc
July 2004
Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, Columbia, South Carolina 29208, USA.
The Watson-Crick DNA double helix is an averaged ideal of multitudinous natural sequence-directed local structural deviations. By effectively derailing normal cellular physiological processes, damaged bases can induce noncanonical irregularities in the local structure of DNA if not efficiently repaired. Pyrimidine bases, especially thymine, are prone to dimerization when exposed to ultraviolet light.
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