Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.parkreldis.2010.06.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer's disease.
PLoS One
January 2025
Department of Neurology, Weill Cornell Medicine, New York, NY, United States of America.
Testosterone, an essential sex steroid hormone, influences brain health by impacting neurophysiology and neuropathology throughout the lifespan in both genders. However, human research in this area is limited, particularly in women. This study examines the associations between testosterone levels, gray matter volume (GMV) and cerebral blood flow (CBF) in midlife individuals at risk for Alzheimer's disease (AD), according to sex and menopausal status.
View Article and Find Full Text PDFCorrelation between the genotype, lifestyle habits, and cognitive deficits in Chinese adults over 60: a cross-sectional analysis in China.
Front Public Health
December 2024
Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: is regarded as the most significant genetic contributor linked to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Daily life elements might also influence cognitive abilities to some extent. This research aimed to investigate whether carrying alters the effects of lifestyle on cognitive ability.
View Article and Find Full Text PDFBrain age gap, dementia risk factors and cognition in middle age.
Brain Commun
November 2024
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SP, UK.
Article Synopsis
- - Brain Age Gap is related to dementia in older adults, but its link to dementia risk-factors and cognitive performance in middle-aged individuals is less explored.
- - A study involving 552 cognitively healthy middle-aged participants showed that brain age gap correlates with factors like hypertension and alcohol intake, but not with genetic risk factors (like the APOE ε4 allele) or cognitive performance.
- - Findings suggest that addressing modifiable risk factors may help in developing therapies to prevent dementia in middle-aged populations.
ApoE: The Non-Protagonist Actor in Neurological Diseases.
Genes (Basel)
October 2024
Clinical Neurochemistry Unit and Biobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, 00179 Rome, Italy.
Article Synopsis
- - ApoE is a glycoprotein critical for lipid transport and metabolism, with the E4 allele being a known risk factor for Alzheimer's disease and potentially other neurological disorders like Parkinson's disease and brain trauma.
- - Recent findings suggest that the E4 allele is linked to worse clinical outcomes in various neurological conditions, mainly through its role in processes like amyloid-β accumulation and neuroinflammation.
- - This review aims to summarize the role of ApoE in neurodegenerative diseases and discuss the ethical considerations surrounding genetic testing for APOE variants, emphasizing its clinical significance.
Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk.
Neurology
November 2024
From the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.
Background And Objectives: The 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, including stroke, late-life depression (LLD), and dementia. A higher BCS at baseline is associated with a lower risk of these outcomes. We aimed to investigate whether the associations between BCS and stroke, LLD, and dementia risks are independent of genetic predisposition for these conditions and quantify the effect of healthy lifestyle across genetic risk distributions for these outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!