AI Article Synopsis
- A one-pot reaction method was developed to efficiently synthesize stable phosphonate ylides and esters using activated acetylenes and triphenylphosphite, along with sulfonamides and NH-acids.
- Characterization of the resulting ylides and phosphonate esters was conducted through single X-ray diffraction and NMR studies.
- Dynamic NMR studies on a phosphonate ylide enabled the determination of the free energy barrier for the isomerization between the (E) and (Z) geometrical forms.
Article Abstract
An efficient synthesis of stable phosphonate ylides and phosphonate esters is described via a one-pot reaction between activated acetylenes and triphenylphosphite in the presence of sulfonamides and heterocyclic NH-acids. Single X-ray diffraction analysis and NMR studies were used in characterizing the ylides and phosphonate ester products. Dynamic NMR studies performed on a phosphonate ylide allowed the calculation of the free energy barrier for the inter-conversion between the geometrical isomers (E) and (Z).
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| http://dx.doi.org/10.2174/1386207311107010002 | DOI Listing |
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