An efficient enantioselective total synthesis of the potent antibiotic GSK966587 was accomplished. Highlights of the synthesis include two innovative Heck reactions, a highly selective zincate base directed ortho-metalation, Sharpless asymmetric epoxidation, and a fully convergent final step fragment coupling.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol101235f | DOI Listing |
Publication Analysis
Top Keywords
target-directed synthesis
4
synthesis antibacterial
4
antibacterial drug
4
drug candidate
4
candidate gsk966587
4
gsk966587 efficient
4
efficient enantioselective
4
enantioselective total
4
total synthesis
4
synthesis potent
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!