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Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine.
Front Biosci (Landmark Ed)
January 2025
Department of Surgery, Laboratory of Tumor Immunology and Immunotherapy, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Immunology advances have increased our understanding of autoimmune, auto-inflammatory, immunodeficiency, infectious, and other immune-mediated inflammatory diseases (IMIDs). Furthermore, evidence is growing for the immune involvement in aging, metabolic and neurodegenerative diseases, and different cancers. However, further research has indicated sex/gender-based immune differences, which further increase higher incidences of various autoimmune diseases (AIDs), such as systemic lupus erythematosus (SLE), myasthenia gravis, and rheumatoid arthritis (RA) in females.
View Article and Find Full Text PDFEnterprise internal audit data encryption based on blockchain technology.
PLoS One
January 2025
Taiyuan University, Taiyuan, China.
Internal auditing demands innovative and secure solutions in today's business environment, with increasing competitive pressure and frequent occurrences of risky and illegal behaviours. Blockchain along with secure databases like encryption improves internal audit security through immutability and transparency. Hence integrating blockchain with homomorphic encryption and multi-factor authentication improves privacy and mitigates computational overhead.
View Article and Find Full Text PDFA framework of ecological security patterns in arid and semi-arid regions considering differences socioeconomic scenarios in ecological risk: Case of Loess Plateau, China.
J Environ Manage
January 2025
School of Surveying and Land Information Engineering, Henan Polytechnic University, Jiaozuo, Henan, 454003, China. Electronic address:
Understanding the establishment of ecological security patterns in arid and semi-arid regions is critical for global ecological risk prevention, control, and sustainable development. Nonetheless, there remains a relative deficiency in ecological risk assessment and construction of Ecological Security Patterns (ESP) in these areas, along with insufficient verification regarding the changes in ecological security patterns under diverse scenarios. This study employs Morphological Spatial Pattern Analysis (MSPA) to identify ecological sources and utilizes circuit theory alongside Minimum Cumulative Resistance (MCR) to delineate ecological corridors.
View Article and Find Full Text PDFOrganizational on-boarding practices and shifts in alcohol misuse among at-risk college recruits.
Int J Hum Resourc Manag
September 2024
Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
With a significant proportion of college students in many countries engaging in risky drinking behavior, this study examines the tendency of such young adults to 'mature out' of such behavior in their first year of employment after graduating, and the degree to which three mainstream organizational on-boarding experiences may expedite such 'maturing out'. Focusing on newcomers' experiences with alcohol-oriented job orientation, job empowerment, and organizational efforts to facilitate the development of supportive peer relationships, we test hypotheses regarding the direct effects of time on the change in alcohol misuse among those reporting misuse in college, as well as the degree to which individual on-boarding experiences account for the variance in young adults' maturing out trajectories over the course of their first year of employment. Findings generated from data collected from over 400 young adults over multiple waves offer important theoretical and practical implications regarding how and why particular onboarding tactics may be more or less effective in influencing newcomers' health-related behaviors.
View Article and Find Full Text PDFThe effect of job loss on risky financial decision-making.
Proc Natl Acad Sci U S A
January 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Job loss is a common and disruptive life event. It is known to have numerous long-term negative effects on financial, health, and social outcomes. While the negative effects of becoming unemployed on health and well-being are well understood, the influence of job loss on financial decisions has received little attention.
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