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Efficacy of laundry practices in eliminating monkeypox virus (MPXV) from fabrics.
J Infect Dis
December 2024
Department of Civil Engineering, University of British Columbia, 2002-6250 Applied Science Lane, Vancouver, British Columbia V6T 1Z4, Canada.
Background: The declaration of mpox as a Public Health Emergency of International Concern highlights the need for interventions to interrupt virus transmission, including transmission via fabrics. Current World Health Organization guidance on clothes washing is based on a general consensus of virus inactivation; however, there is uncertainty about the efficacy of laundry detergents and disinfectants or the reduction of risk achieved by washing clothes for monkeypox virus (MPXV) specifically.
Methods: This study investigates the efficacy of manual washing for inactivating MPXV from clothes.
High-Throughput Tear Proteomics via In-Capillary Digestion for Biomarker Discovery.
Int J Mol Sci
November 2024
Retina Department, Sewickley Eye Group, Sewickley, PA 15143, USA.
Article Synopsis
- Tear fluid is a useful source for biomarker discovery, but challenges like small sample volume and inconsistent collection methods hinder its analysis.
- The study introduces a new high-throughput method for processing tear fluid using just 0.5 μL, which simplifies handling and reduces processing time compared to traditional approaches.
- This method achieved a four-fold increase in the number of proteins identified, demonstrating the effectiveness of microcapillary collection and the potential for improved biomarker discovery in tear proteomics.
Field-deployable pencil lead-based electrochemical cell for the determination of the emerging contaminant and antidepressant drug venlafaxine in wastewater.
Biosens Bioelectron
January 2025
Departamento de Química Física y Analítica, Universidad de Oviedo, 33006, Oviedo, Spain. Electronic address:
Screening and quantification of emerging contaminants in water is of enormous relevance due to its scarcity and harmful effects on aquatic life and human health. We present a simple and cost-effective electrochemical cell for determination of the antidepressant venlafaxine, an emerging contaminant included in the EU Watch list 2022. The cell consists of pencil leads used as electrodes and a microcentrifuge tube.
View Article and Find Full Text PDFA gold nanoparticle (AuNP)-supported rapid, electronic detection (NasRED) platform is demonstrated with high specificity to differentiate SARS-CoV-2 from human coronaviruses while achieving high sensitivity. Uniquely, active fluidic force is exerted on AuNPs in a microcentrifuge tube, through engineered centrifugation and vortex agitation, to accelerate signal transduction from biochemical protein binding to physical AuNP aggregation and precipitation and finally to electronic signals in a customized, stabilized circuitry. The limits of detection are found <80 aM (12 fg/mL) and ∼700 aM (105 fg/mL) to detect antibodies in human pooled serum and 20% diluted whole blood, and <900 aM (45 fg/mL) and 4.
View Article and Find Full Text PDFDual-enhanced enzyme cascade hybrid hydrogel for the construction of optical biosensor.
Biosens Bioelectron
November 2024
Key Laboratory of Advanced Gas Sensors, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, PR China. Electronic address:
The biomimetic enzyme cascade system plays a key role in biosensing as a sophisticated signal transduction and amplification strategy. However, constructing a regulated enzyme cascade sensing system remains challenging due to the mismatch of multiple enzyme activities and poor stability. Herein, we design an efficient dual-enhanced enzyme cascade hybrid system (UFD-DEC) containing DNA-controlled nanozymes (Fe-cdDNA) and enzyme (urease) via combining the electrostatic contact effect with the hydrogel-directed confinement effect.
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