AI Article Synopsis
- - The study investigated how endothelin-1 (ET-1) affects the development of retinitis pigmentosa (RP) by comparing plasma ET-1 levels in RP patients to healthy individuals.
- - Results showed that RP patients had significantly lower mean plasma ET-1 levels than the control group, but individual ET-1 levels varied widely among patients and didn't correlate with specific hereditary forms or clinical features.
- - The findings suggest that ET-1 might play a role in the progression of RP, and measuring its levels could provide valuable insights into the blood flow dynamics in the retina of affected individuals.
Article Abstract
Purpose: The aim of this study was to elucidate the role of endothelin-1 (ET-1) in the pathophysiology of retinitis pigmentosa (RP).
Methods: Plasma ET-1 levels and ophthalmic features in 50 RP patients were compared with those in 20 healthy-eye control subjects. Plasma ET-1 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit.
Results: Mean plasma ET-1 levels of RP patients (1.88 +/- 0.56 pg/mL) were significantly lower than those of control subjects (2.30 +/- 0.30 pg/mL, Mann-Whitney's U test; P < 0.01). However, ET-1 concentrations varied markedly in each patient. Among RP patients, a significant correlation of ET-1 concentrations was not observed in terms of its hereditary forms or other clinical factors.
Conclusion: ET-1 may be important in the pathogenesis of RP, and measurement of its plasma concentrations may also contribute to additional insights into the retinal hemodynamics of RP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909885 | PMC |
| http://dx.doi.org/10.2147/opth.s9152 | DOI Listing |
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