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Investigation of pure lung microbiota in patients with lung cancer after eliminating upper airway contamination: a prospective cohort study.
J Thorac Dis
November 2024
Department of General Thoracic Surgery, Japanese Red Cross Suwa Hospital, Suwa, Nagano, Japan.
Background: While the relationship between gut microbiota and gastrointestinal cancer has been elucidated, the relationship between lung microbiota and lung cancer remains unclear. Previous study findings are inconclusive due to the possibility of contamination by upper airway microbiota in samples obtained from the oropharynx, such as saliva and sputum, and bronchoalveolar lavage fluid (BALF) collected during bronchoscopy. Therefore, this study aimed to detect pure lung microbiota in patients with lung cancer using BALF samples from resected lung specimens.
View Article and Find Full Text PDFExploring aggregation genes in a chronic infection model.
J Bacteriol
December 2024
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Unlabelled: Bacterial aggregates are observed in both natural and artificial environments. In the context of disease, aggregates have been isolated from chronic and acute infections. () aggregates contribute significantly to chronic infections, particularly in the lungs of people with cystic fibrosis (CF).
View Article and Find Full Text PDFNeutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in cystic fibrosis.
ERJ Open Res
November 2024
The University of Edinburgh/Centre for Inflammation Research, Edinburgh Bioquarter, Edinburgh, UK.
Article Synopsis
- Cystic fibrosis (CF) is characterized by heightened neutrophil presence in the airways and inefficient apoptosis, prompting the investigation of whether NETosis (a form of neutrophil clearance) plays a significant role in CF lung disease.
- In a study involving 45 CF and 15 healthy participants, researchers found higher neutrophil counts and abnormal morphology in CF sputum, alongside elevated levels of inflammatory mediators and NETs, indicating a strong link between NETs and airway inflammation.
- Treatment with DNase reduced sputum NET levels and mitigated the pro-inflammatory effects of NETs in co-culture experiments, highlighting its potential as an anti-inflammatory therapy in CF management.
Association between humidity and respiratory health: the 2016-2018 Korea National Health and Nutrition Examination Survey.
Respir Res
December 2024
Division of Allergy and Respiratory Diseases, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Seoul, 04401, Republic of Korea.
Background: Ambient humidity has a significant impact on respiratory health and influences disease and symptoms. However, large-scale studies are required to clarify its specific effects on lung function and respiratory symptoms. We examined the relationship between relative humidity (RH), lung function, and respiratory symptoms using data from the Korea National Health and Nutrition Examination Survey (KNHANES).
View Article and Find Full Text PDFCetuximab-Induced Pneumonitis: An Overlooked Complication.
Cureus
October 2024
Pulmonary and Critical Care Medicine, St. Michael's Medical Center, Newark, USA.
Epidermal growth factor receptor (EGFR) inhibitors have largely been used for head and neck cancers, non-small cell lung cancers, and colorectal cancers (CRC). Reports of interstitial pneumonitis with EGFR inhibitors like gefitinib and erlotinib are present in the literature, but pulmonary toxicity with cetuximab has rarely been reported. We present a case of a 78-year-old male with metastatic CRC involving the brain and lungs who presented with severe pneumonitis, a month after treatment with cetuximab.
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