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Aseptic meningitis from herpes simplex virus proctitis.
BMJ Case Rep
January 2025
Graduate Medical Education, University of Miami Miller School of Medicine, Fort lauderdale, Florida, USA.
Sexually transmitted proctitis, a prevalent concern among men who have sex with men (MSM) is frequently caused by a range of pathogens, including herpes simplex virus (HSV), and While HSV-associated proctitis typically presents with visible lesions, cases without external manifestations remain evasive. We report the case of an MSM in his early 30s presenting with dyschezia and perineal discomfort after unprotected anoreceptive intercourse. Despite initial inconspicuous findings, rectal swabs revealed HSV-2 infection.
View Article and Find Full Text PDFEmergence of ceftriaxone-resistant Neisseria gonorrhoeae through horizontal gene transfer among Neisseria spp.
J Infect Dis
January 2025
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
Objectives: It has been suggested that the emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae involves the incorporation of the penA gene from commensal Neisseria spp. that are resistant to ceftriaxone. However, the mechanism of this mosaic penA generation is unknown.
View Article and Find Full Text PDFCommunity pharmacies: Key players in point-of-care diagnostics for STI screening in Africa.
PLoS One
January 2025
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Background: Sexually Transmitted Infections (STIs) rank in the top 5 disease categories for which adults in developing countries seek healthcare services. Community pharmacies offer clients convenience, proximity, extended opening hours, privacy, and efficiency, which could make them desirable locations for HIV and STI screening and treatment. We examined the feasibility of using point-of-care (POC) STI tests for screening HIV and other STIs at community pharmacies.
View Article and Find Full Text PDFCould have carcinogenic potential? A critical review of current evidence.
Crit Rev Microbiol
January 2025
School of Biomedical Sciences at Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, QLD, Australia.
There is growing evidence that microbial dysbiosis is intimately related to carcinogenesis across several types of human cancer. is best known for causing acute exudative genitourinary infection in males. can also cause chronic, asymptomatic infection of the female genitourinary tract along with the oropharynx and rectum of both sexes.
View Article and Find Full Text PDFProtective Antimicrobial Effect of the Potential Vaccine Created on the Basis of the Structure of the IgA1 Protease from .
Vaccines (Basel)
November 2024
Laboratory of Proteolytic Enzyme Chemistry, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
IgA1 protease is one of the virulence factors of , and other pathogens causing bacterial meningitis. The aim of this research is to create recombinant proteins based on fragments of the mature IgA1 protease A-P from serogroup B strain H44/76. These proteins are potential components of an antimeningococcal vaccine for protection against infections caused by pathogenic strains of and other bacteria producing serine-type IgA1 proteases.
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