AI Article Synopsis
- The study focused on the DAOA/G30 gene complex at chromosome 13q32-33, which is linked to major psychiatric disorders, but previous research has been inconclusive about specific risk factors.
- Researchers analyzed seven SNPs in a sample of 248 patients with affective psychosis and 188 controls, looking for genetic associations using different classification approaches.
- Findings indicated that no single SNP was associated with affective disorders overall; however, specific haplotypes showed some association with manic-depression and monopolar depression in a subgroup, suggesting more complex genetic influences rather than a common genetic risk across all affective disorders.
Article Abstract
Background: The DAOA/G30 (D-amino acid oxidase activator) gene complex at chromosomal region 13q32-33 is one of the most intriguing susceptibility loci for the major psychiatric disorders, although there is no consensus about the specific risk alleles or haplotypes across studies.
Methods: In a case-control sample of German descent (affective psychosis: n = 248; controls: n = 188) we examined seven single nucleotide polymorphisms (SNPs) around DAOA/G30 (rs3916966, rs1935058, rs2391191, rs1935062, rs947267, rs3918342, and rs9558575) for genetic association in a polydiagnostic approach (ICD 10; Leonhard's classification).
Results: No single marker showed evidence of overall association with affective disorder neither in ICD10 nor Leonhard's classification. Haplotype analysis revealed no association with recurrent unipolar depression or bipolar disorder according to ICD10, within Leonhard's classification manic-depression was associated with a 3-locus haplotype (rs2391191, rs1935062, and rs3916966; P = 0.022) and monopolar depression with a 5-locus combination at the DAOA/G30 core region (P = 0.036).
Conclusion: Our data revealed potential evidence for partially overlapping risk haplotypes at the DAOA/G30 locus in Leonhard's affective psychoses, but do not support a common genetic contribution of the DAOA/G30 gene complex to the pathogenesis of affective disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921107 | PMC |
| http://dx.doi.org/10.1186/1471-244X-10-59 | DOI Listing |
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The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach.
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Article Synopsis
- The study focused on the DAOA/G30 gene complex at chromosome 13q32-33, which is linked to major psychiatric disorders, but previous research has been inconclusive about specific risk factors.
- Researchers analyzed seven SNPs in a sample of 248 patients with affective psychosis and 188 controls, looking for genetic associations using different classification approaches.
- Findings indicated that no single SNP was associated with affective disorders overall; however, specific haplotypes showed some association with manic-depression and monopolar depression in a subgroup, suggesting more complex genetic influences rather than a common genetic risk across all affective disorders.
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Arch Gen Psychiatry
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Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University.
Context: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association.
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