AI Article Synopsis
- This study examined how mycelial extract and culture filtrate from Cordyceps sphecocephala J201 impact asthma-related symptoms in animal models.
- After treating mouse spleen cells with Concanavalin A, the extracts significantly reduced levels of the Th2 cytokines IL-4 and IL-13.
- The findings suggest that these extracts might help alleviate asthma by controlling immune cell responses and lowering cytokine levels associated with allergic inflammation.
Article Abstract
This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.
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