Background: The vulva is an extremely rare site for lymphangioma, a benign tumor of the lymphatic vessels. A small number of case reports have described cavernous lymphangioma involving the unilateral labium majus of young women. We report a case of cavernous lymphangiomas involving the bilateral labia minora.
Case: A 14-year-old girl presented with bilateral tumors of the labia minora, which were removed surgically and histologically diagnosed as cavernous lymphangioma. Positive nuclear staining for estrogen and progesterone receptors was demonstrated in the stromal fibroblasts immunohistochemically.
Conclusion: It is suggested that an increase in estrogen and progesterone levels may have led to, or at least affected, the development of these tumors in this patient. Excision followed by cosmetic repair may be the optimal treatment.
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http://dx.doi.org/10.1097/AOG.0b013e3181da0266 | DOI Listing |
Int J Surg Case Rep
January 2025
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Tishreen University, Lattakia, Syria.
Introduction And Importance: Oral Lymphangioma is a rare benign tumor that arises from the lymphatic vessels in oral cavity. It is a development defect in the lymphatic system, which is less common than other types of vascular anomalies, and the incidence in the general population is very low, especially in the oral cavity. It typically presents as soft, painless swelling, often found on the tongue, lips or floor or the mouth.
View Article and Find Full Text PDFSurg Infect (Larchmt)
January 2025
Department of Infectious Diseases, Department of Tuberculosis, Infection, and Immunity Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
J Toxicol Pathol
January 2025
Pathology Department, Kashima Laboratories, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.
We performed morphological and immunohistochemical analyses of erythrocyte-rich vascular proliferative lesions of mesenteric lymph nodes in six male and one female Wistar Hannover rats. These lesions are conventionally diagnosed as hemangiomas due to abundant erythrocytes. Immunostaining was positive for prospero-related homeobox 1 (Prox-1) and/or vascular endothelial growth factor receptor 3 (VEGFR3) in all lesions, suggesting a lymphangitic origin.
View Article and Find Full Text PDFEndocrine
January 2025
Anatomic Pathology - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Purpose: Adrenal vascular tumors are mainly represented by adrenal cavernous hemangiomas (ACHs) and adrenal cystic lymphangiomas (ACLs). Their radiological features often overlap with malignant tumors, therefore ruling out malignancy becomes mandatory. We analyzed clinical, radiological, and histopathological data to identify specific characteristics of these tumors.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics and Gynecology, First Health Cluster, Dammam, SAU.
Mediastinal lymphangiomas are rare benign tumors arising from lymphatic system malformations, most commonly seen in pediatric populations. In adults, they are exceedingly rare and present diagnostic challenges due to nonspecific symptoms and imaging overlap with other mediastinal masses. Diagnosis is typically based on imaging, including CT and MRI, with histopathology confirming the diagnosis.
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