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The effects of single testosterone administration and stress induction on steroid hormone levels in hair.
Psychoneuroendocrinology
November 2024
Experimental Pharmacopsychology, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8008, Switzerland; Neuroscience Center Zurich, ETH Zurich and University of Zurich, Zurich 8057, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich 8050, Switzerland.
Hair steroid analysis is increasingly recognized for its ability to capture cumulative hormone secretion, thought to reflect an individual's response to long-term environmental conditions. Despite its growing use, the influence of single, isolated events on hair steroid concentrations remains underexplored. Our study therefore examined the effects of a single-dose transdermal testosterone administration (150 mg) and acute laboratory stress induction on hair testosterone and cortisol levels in a randomized, between-subject, placebo-controlled, and double-blind design.
View Article and Find Full Text PDFImproving growth and development in children with growth hormone deficiency through transdermal treatment of acupoints with the tonifying spleen and kidney method in conjunction with growth hormone therapy.
Pak J Pharm Sci
September 2024
Department of Respiratory Medicine, Zhenhai District Hospital of Chinese Medicine, Zhejiang, China/Chinese Traditional Medicine, Southern Medical University, Guangdong, China.
This retrospective analysis aimed to evaluate the potential benefits of integrating transdermal acupoint therapy with the tonifying spleen and kidney method alongside growth hormone (GH) treatment for pediatric patients suffering from growth hormone deficiency (GHD). Clinical data of 115 pediatric patients with GHD were retrospectively analyzed. Patients were categorized into two distinct groups for the analysis: The conventional GH treatment group (n=62) and the combined group of acupoint transdermal therapy alongside GH treatment (n=53).
View Article and Find Full Text PDFExamining the Influence of the Route of Administration and Dose of Estradiol on Serum Estradiol and Testosterone Levels in Feminizing Gender-Affirming Hormone Therapy.
Endocr Pract
January 2025
Division of Endocrinology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Transgender Medicine and Surgery, Mount Sinai Health System, New York, New York.
Introduction: Individuals may seek gender-affirming hormone therapy (GAHT) to align their physical appearance with their gender identity. Feminizing GAHT typically involves the use of estrogen. This study investigates the effect of route of administration (ROA) and dose of estradiol on estradiol (E2) and testosterone (T) levels in transfeminine individuals.
View Article and Find Full Text PDFClostebol and sport: about controversies involving contamination vs. doping offence.
Clin Chem Lab Med
October 2024
Department of Chemistry, University of Turin, Turin, Italy.
Clostebol, the 4-chloro derivative of testosterone, available as Over The Counter product in pharmacies and drugstores in several countries, is mostly commercialized as a cream or spray in the form of acetate ester. As other anabolic steroids, clostebol is listed as a prohibited substance by the World Anti-Doping Agency (WADA). Controlled transdermal application of clostebol acetate has been reported to produce detectable amounts of its metabolites in urine, even after a single exposure.
View Article and Find Full Text PDFTestosterone Therapy in Men After Radical Prostatectomy for Low-Intermediate Organ-Confined Prostate Cancer.
J Urol
January 2025
Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Article Synopsis
- - The study aimed to evaluate whether testosterone therapy (TTh) affects the rates of biochemical recurrence (BCR) in men with low-intermediate prostate cancer who have undergone radical prostatectomy (RP).
- - A total of 5,199 men were studied, with 198 receiving TTh post-RP; the analysis adjusted for factors like age and preoperative PSA levels.
- - Results showed a slightly lower risk of BCR in men on TTh, but overall BCR rates were low in both groups, suggesting TTh can be safe for select men after RP without increasing BCR risk.
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