AI Article Synopsis
- Malignant glioma is a severe brain tumor with a high risk of recurrence and mortality, even with treatment options like surgery and chemotherapy.
- The study combines focused ultrasound to temporarily open the blood-brain barrier and an external magnetic field to enhance the delivery of a chemotherapy drug using specialized magnetic nanoparticles.
- This method significantly improved drug delivery in rodent models, effectively suppressing tumor growth while sparing normal brain tissue, and allows for monitoring via MRI, offering a promising, less invasive treatment approach.
Article Abstract
Malignant glioma is a common and severe primary brain tumor with a high recurrence rate and an extremely high mortality rate within 2 years of diagnosis, even when surgical, radiological, and chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because of their adverse systemic effects and poor blood-brain barrier penetration. Here, we combine 2 methods to increase drug delivery to brain tumors. Focused ultrasound transiently permeabilizes the blood-brain barrier, increasing passive diffusion. Subsequent application of an external magnetic field then actively enhances localization of a chemotherapeutic agent immobilized on a novel magnetic nanoparticle. Combining these techniques significantly improved the delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea to rodent gliomas. Furthermore, the physicochemical properties of the nanoparticles allowed their delivery to be monitored by magnetic resonance imaging (MRI). The resulting suppression of tumor progression without damaging the normal regions of the brain was verified by MRI and histological examination. This noninvasive, reversible technique promises to provide a more effective and tolerable means of tumor treatment, with lower therapeutic doses and concurrent clinical monitoring.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018928 | PMC |
| http://dx.doi.org/10.1093/neuonc/noq054 | DOI Listing |
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