AI Article Synopsis
- Oxidized phospholipids (Ox-PLs), typically associated with inflammation, may also have anti-inflammatory effects.
- A synthetic Ox-PL analog called VB-201 was tested for its benefits on autoimmune inflammatory disease in the central nervous system (CNS).
- Oral treatment with VB-201 reduced the severity of autoimmune encephalomyelitis (EAE) and inhibited the activation of T-cells responsible for the disease, suggesting a new potential for Ox-PLs in treating CNS inflammatory conditions.
Article Abstract
Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.
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| http://dx.doi.org/10.1016/j.jneuroim.2010.06.011 | DOI Listing |
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