AI Article Synopsis
- The link between coagulation disorders and (recurrent) ischemic stroke remains unclear, raising questions about the value of screening stroke patients for these conditions.
- The review examines various inherited and acquired coagulation abnormalities, such as factor V Leiden and antiphospholipid syndrome, and their potential relationship with ischemic stroke.
- The article discusses whether screening for prothrombotic conditions is beneficial for stroke patients and explores recommended strategies for managing those diagnosed with a coagulation disorder.
Article Abstract
The role of coagulation disorders in the pathogenesis of (recurrent) ischemic stroke is uncertain. Therefore, the clinical utility of screening patients with ischemic stroke for these conditions and the therapeutic implications of a detected coagulation disorder in a patient who experienced ischemic stroke are uncertain. We reviewed the currently available data on the relationship between various inherited and acquired coagulation abnormalities (factor V Leiden and prothrombin G20210A mutations, deficiencies of protein C, protein S and anti-thrombin, hyperhomocysteinemia, the antiphospholipid syndrome and increased levels of fibrinogen) and ischemic stroke. Based on the existing evidence we discuss the usefulness of screening stroke patients for prothrombotic conditions and current recommendations regarding the optimal management of ischemic stroke patients in whom a coagulation disorder is found.
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| http://dx.doi.org/10.1586/ern.10.104 | DOI Listing |
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