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Presence of aspartate aminotransferase in peri-implant crevicular fluid with and without mucositis. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate the levels of aspartate aminotransferase (AST) in the fluid around dental implants to see if it can predict mucositis and assess its diagnostic value.
  • AST levels were measured before and after probing of the implants in 25 patients with varying degrees of mucositis, revealing significant differences in AST levels based on clinical conditions.
  • The findings suggest that higher AST levels can indicate the presence of mucositis, making it a useful diagnostic tool, particularly since probing inflamed tissues leads to a greater release of AST.

Article Abstract

The aim of this study was to assess the presence of aspartate aminotransferase (AST) in peri-implant crevicular fluid, with or without clinical signs of mucositis, to determine its predictive diagnostic value, sensitivity, and specificity. The AST levels were determined (at a threshold of 1200 µIU/mL) for 60 clinically successful implants in 25 patients with or without peri-implant mucositis. Samples were taken prior (AST1) to peri-implant probing with a manual constant-pressure probe (0.2 N) and 15 minutes after probing (AST2). Clinical assessments included radiographic determination of preexisting bone loss, probing, and the evaluation of mucositis, plaque, and bleeding upon probing. Analysis was performed at both the level of the implant and the patient as a unit. We detected a significant difference between AST1 and AST2 at both levels. A significant difference was observed at AST1 between implants that bled upon probing and those that did not. However, when we considered the patient as a unit, there were no significant differences. The plaque index was not significant at either level. AST1 had high specificity and positive predictive diagnostic value (80%) for bleeding upon probing. Probing induces a greater release of AST from inflamed tissues compared with healthy tissues in situ but not at the systemic level. At the implant level, the implant position could be responsible for this difference. Aspartate aminotransferase was a reliable predictor of patients with mucositis.

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Source
http://dx.doi.org/10.1563/AAID-JOI-D-10-00055DOI Listing

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