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Cognition, emotions and quality of life in Lithuanian girls with Turner syndrome after growth hormone therapy discontinuation. | LitMetric
Objective : to examine cognitive functions, emotional state and quality of life of patients with Turner syndrome (TS) after growth hormone therapy discontinuation.Patients And Methods : Anthropometric measurements, cognitive functioning, emotional state and quality of life of eighteen Lithuanian patients with TS were compared to that of age- and sex-matched controls. Height and weight of girls with TS were significantly lower than in the controls, though differences in body mass index were not significant.Results : Tension-anxiety (10.61 +/- 7.21 vs. 6.72 +/- 3.98, p=0.02) and depression-dejection (14.72 +/- 11.87 vs. 8.49 +/- 6.29, p=0.02) were significantly higher, vigor-activity (13.05 +/- 4.77 vs. 16.13 +/- 4.36, p=0.04) was significantly lower and scores of cognitive functioning (53.18 +/- 29.46 vs. 26.79 +/- 7.31 and 96.94 +/- 44.59 vs. 58.07 +/- 15.43, p=0.001) were significantly higher (showing worse psychomotoric speed) in patients with TS than in the controls. Quality of life (9.53 +/- 5.19 vs. 6.35 +/- 4.19, p=0.03) in girls with TS was significantly worse than in healthy girls of the same age.Conclusion : patients with Turner syndrome are shorter, have lower weight, higher waist-to-hip ratio, impaired cognitive functions (worse psychomotoric speed), altered emotional state (higher tension-anxiety and depression-dejection, lower vigor-activity scores) and lower quality of life than age- and sex-matched controls.
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