Cardiac arrhythmias are often observed in patients during perioperative period. There are many types of arrhythmias, and some of these can be independent predictors of morbidity and mortality in patients undergoing both cardiac and non-cardiac surgery. In accordance with patients' condition, advanced cardiac testing may be needed for predicting and reducing the perioperative risk. The preoperative management is also an important component of the preparation of the surgical patients with arrhythmias. Most arrhythmias may be associated with cardiac or non-cardiac problems, such as cardiopulmonary disease, myocardial ischemia, drug toxicity, endocrine disease, or metabolic derangements. Since perioperative arrhythmias may increase their risk dependent on the underlying cause, these abnormalities should be corrected if possible before surgery.
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BMC Anesthesiol
January 2025
Department of Anesthesia, College of Medicine and Health Sciences, Bahir Dar University, PO Box 79, Bahir Dar, Ethiopia.
Introduction: In a low-income country, the impact of preoperative anemia on postoperative mortality among noncardiac surgery patients is little understood. As a result, we aim to investigate the association between preoperative anemia and postoperative mortality in noncardiac surgery patients in Northwest Ethiopia.
Methods: This is a prospective follow-up study of 3506 noncardiac surgery patients who were included in the final analysis between June 1, 2019, and July 1, 2021.
J Interv Card Electrophysiol
January 2025
Cardiovascular Department, University of Texas Medical Branch, Galveston, TX, USA.
Background: Ventricular tachycardia (VT) in patients with cardiac sarcoidosis (CS) can lead to sudden cardiac death. The role of ventricular tachycardia ablation (VTA) in CS has been investigated in a few small, single-center, and larger observational studies, but the evidence still needs to be provided. This study aimed to investigate the clinical outcomes of VTA in patients with CS admitted with a diagnosis of VT.
View Article and Find Full Text PDFBackground: Postoperative delirium (POD) is characterized by fluctuating attention after surgery and is associated with increased risk of developing Alzheimer's Disease (AD). While the neurophysiological changes that underlie POD and increased risk of AD are unclear, recent data has raised the possibility that an exaggerated brain response to anesthetics may be a biomarker for POD risk and preclinical AD-like pathology. Thus, we examined whether anesthetic-dose-adjusted intraoperative brain activity is associated with POD or preoperative brain vulnerabilities (preclinical AD-like pathology, preoperative inattention) that may contribute to risk of POD (and later AD).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Neurology Department, Duke University, Durham, NC, USA.
Background: APOE4 leads to increased neuroinflammation, neurocognitive decline, increased risk of Alzheimer's disease, and may be associated with increased delirium risk. However, the safety and feasibility of pharmacologic modulation of APOE to prevent neuroinflammation and postoperative delirium is unclear.
Methods: We performed a Phase II, triple blind, escalating dose, randomized controlled trial to determine the safety, feasibility, and efficacy of the APOE mimetic peptide CN-105 for preventing postoperative neuroinflammation and delirium.
Background: Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF).
Aims: This study aimed to characterize patients with exertional dyspnoea and normal/near-to-normal N-terminal pro-brain natriuretic peptide (NT-proBNP) levels with regard to early stages of HFpEF and non-cardiac causes.
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