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This study assesses the association between intake of protein, fats, cholesterol, and carbohydrates and the risk of prostate cancer (PCa). Between 1994 and 1997, in 8 Canadian provinces, mailed questionnaires were completed by 1,797 incident, histologically confirmed cases of PCa and 2,547 population controls. Information was collected on socioeconomic status, lifestyle habits, and diet. A 69-item food frequency questionnaire provided data on eating habits 2 yr before the study. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using unconditional logistic regression, including terms for sociodemographic factors, body mass index, alcohol, and total energy intake. Intake of trans fat was associated with the risk of PCa; the OR for the highest vs. the lowest quartile was 1.45 (95% CI = 1.16-1.81); the association was apparently stronger in subjects aged less than 65, normal weight men, and ever smokers. An increased risk was also observed with increasing intake of sucrose and disaccharides. In contrast, men in the highest quartile of cholesterol intake were at lower risk of PCa. No association was found with intake of total proteins, total fat, monounsaturated fats, polyunsaturated fats, monosaccharides, and total carbohydrates. The findings provide evidence that a diet low in trans fat could reduce PCa risk.
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http://dx.doi.org/10.1080/01635581003605953 | DOI Listing |
Radiother Oncol
March 2025
Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Jeollanam-do, South Korea.
Med Phys
March 2025
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: Magnetic resonance-guided adaptive radiation therapy (MRgART) systems combine Magnetic resonance imaging (MRI) technology with linear accelerators (LINAC) to enhance the precision and efficacy of cancer treatment. These systems enable real-time adjustments of treatment plans based on the latest patient anatomy, creating an urgent need for accurate and rapid dose calculation algorithms. Traditional CT-based dose calculations and ray-tracing (RT) processes are time-consuming and may not be feasible for the online adaptive workflow required in MRgART.
View Article and Find Full Text PDFProstate
March 2025
Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Background: Cabazitaxel (CBZ) is a key drug used for metastatic castration-resistant prostate cancer (mCRPC). However, clinical trial data on CBZ in very elderly patients are still lacking. This study aimed to investigate the efficacy and feasibility of CBZ for mCRPC patients of ≥ 80 years of age.
View Article and Find Full Text PDFJ Appl Clin Med Phys
March 2025
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Purpose: A new workflow was investigated for Elekta Unity MR-Linac by removing the computed tomography (CT)-simulation step and using diagnostic CT (DCT) for reference plan generation.
Materials And Methods: Ten patients with ultra-hypofractionated prostate cancer treated with magnetic resonance imaging (MRI)-guided adaptive radiotherapy were retrospectively enrolled. Targets and organs at risk (OARs) were recontoured on DCT, and Hounsfield unit conversions to relative electron density were calibrated for DCT.
BMC Urol
March 2025
Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: The aim of this study was to assess the feasibility of using magnetic resonance (MR) images to implement a dose painting (DP) approach in prostate high-dose-rate brachytherapy.
Methods: The study included 45 patients with prostate tumors of varying grades, with the tumors (DILs) manually segmented with a 0.5 cm margin on T2W MR Images.
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