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Migraine-type headaches in children receiving chemotherapy and ondansetron.
J Child Neurol
November 2002
Division of Neurology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Six children developed severe daily migraine-type headaches during cancer treatment. In addition to chemotherapy drugs, all received daily doses of ondansetron, a 5-hydroxytryptamine type 3 receptor antagonist. 5-Hydroxytryptamine is considered to play a central role in migraine pathogenesis, and ondansetron may have caused headaches by producing 5-hydroxytryptamine dysfunction in the brain.
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