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http://dx.doi.org/10.1783/147118910791749399 | DOI Listing |
Reproduction
March 2025
M Kowalewski, Institute of Veterinary Anatomy, University of Zurich Vetsuisse Faculty, Zürich, Switzerland.
Although implantation and parturition are associated with pro-inflammatory signals, inflammatory responses in the mature placenta frequently lead to pregnancy loss. Indeed, uterine inflammatory/infectious diseases are major causes of infertility and pregnancy loss in dogs. The pro-inflammatory interleukin (IL)-1β is increased during canine placentation and downregulated in mature placentae during healthy pregnancies, but is enriched in the placenta during infectious events.
View Article and Find Full Text PDFInt J Surg Pathol
March 2025
Pathology Department, UMFST Targu Mures, Targu Mures, Romania.
IntroductionEndometrial endometrioid carcinomas can show multiple lines of differentiation, including pilomatrix-like high-grade endometrioid carcinoma, a recently described tumor with similarity to cutaneous pilomatrix carcinoma and associated with very aggressive clinical behavior.MethodsWe present a 56-year-old woman with an endometrial tumor associated with secondary involvement of both ovaries, left tubo-ovarian ligament and obturator lymph nodes. The diagnosis of high-grade endometrioid carcinoma in a previously performed curettage was confirmed in the hysterectomy specimen.
View Article and Find Full Text PDFAdv Nanobiomed Res
January 2025
The City College of New York, Department of Biomedical Engineering, New York, NY 10031.
Breast cancer is a substantial source of morbidity and mortality worldwide. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), are the primary biomarkers which inform breast cancer treatment. Although endocrine therapy for ER+ patients is widely available, there is a need for increased access to low cost, rapid and accurate ER testing methods.
View Article and Find Full Text PDFBMC Cancer
March 2025
Department of Radiology, Zhongshan Hospital of Fudan University, No180 Fenglin Road, Xuhui District, Shanghai, 200023, People's Republic of China.
Objective: To investigate associations between breast cancer molecular subtype and intravoxel incoherent motion imaging (IVIM) and amide proton transfer-weighted (APTw).
Methods: This prospective study involved 264 patients with suspected breast tumors who underwent both breast APTw and IVIM MRI. The maximum diameter of the tumor (Dmax), APT value, apparent diffusion coefficient (ADC), diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) values along with histological subtype, grade, and prognostic factors (Ki-67, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), were compared.
Neuropharmacology
March 2025
Department of Disease Model, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kagiya-cho, Kasugai 480-0392, Japan.
Perinatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neonatal death and neurological disorders. We recently demonstrated the neuroprotective effects of nestorone, a progesterone receptor agonist, in adult male rats subjected to focal cerebral ischemia; however, its effects on neonatal ischemic brain injury and on sexual differentiation and reproductive functions remain unclear. Therefore, the present study investigated the effects of nestorone on neonatal hypoxic-ischemic brain injury and reproductive functions in rats of both sexes.
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