AI Article Synopsis
- VDUP1 is involved in various cell functions like growth, death, and differentiation, particularly relating to diseases like cancer and stress.
- The study found that increased levels of VDUP1 in younger cells lead to signs of aging, while reducing VDUP1 can delay aging induced by the Ras protein.
- FOXO3A enhances VDUP1 expression during aging, while the miR-17-5p molecule lowers it, showing that both transcriptional and post-transcriptional mechanisms regulate VDUP1 during cellular senescence.
Article Abstract
Vitamin D(3) up-regulated protein 1 (VDUP1) plays multifunctional roles in diverse cellular responses, particularly in its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases. In this study, we demonstrated that VDUP1 was up-regulated during the senescence process. Our results showed that overexpression of VDUP1 in young cells caused typical signs of senescence. We also found that VDUP1 knockdown delayed the onset of Ras-induced cellular senescence. Subsequently, we found that FOXO3A, whose activity increased in senescent cells, transcriptionally up-regulates VDUP1 expression and miR-17-5p, whose expression decreased in senescent cells, directly interacted with the 3'-untranslated region of VDUP1 transcripts, and destabilized VDUP1 mRNA in young cells. These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951223 | PMC |
| http://dx.doi.org/10.1074/jbc.M109.068387 | DOI Listing |
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