AI Article Synopsis
- The dichloromethane (MKD) and ethyl acetate (MKE) extracts from Murraya koenigii leaves effectively reduced body weight gain and lowered plasma total cholesterol and triglyceride levels in obese rats fed a high fat diet over two weeks.
- The beneficial effects of these extracts are linked to the presence of carbazole alkaloids, which are thought to contribute to their anti-obesity and antihyperlipidemic properties.
- Additionally, the compound mahanimbine, administered at a lower dose, also showed significant weight and lipid level reduction, highlighting its potential as a preventive treatment for obesity.
Article Abstract
The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity.
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| http://dx.doi.org/10.1016/j.fitote.2010.07.013 | DOI Listing |
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