AI Article Synopsis
- Researchers synthesized N-aryl-3-(indol-3-yl)propanamides and tested their immunosuppressive effects.
- The compound 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 showed strong effectiveness in inhibiting the proliferation of murine splenocytes in lab tests.
- Additionally, it exhibited significant immunosuppressive activity in a live mouse model, demonstrating its potential for further development.
Article Abstract
N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.
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| http://dx.doi.org/10.1016/j.bmcl.2010.07.001 | DOI Listing |
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