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Impact of Oxidative Stress and Neuroinflammation on Sarco/Endoplasmic Reticulum Ca-ATPase 2b Downregulation and Endoplasmic Reticulum Stress in Temporal Lobe Epilepsy.
ACS Pharmacol Transl Sci
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari, Kamrup, Assam 781101, India.
Epilepsy is one of the most common neurological disorders. Calcium dysregulation and neuroinflammation are essential and common mechanisms in epileptogenesis. Sarco/endoplasmic reticulum (ER) Ca-ATPase 2b (SERCA2b), a crucial calcium regulatory pump, plays pathological roles in various calcium dysregulation-related diseases.
View Article and Find Full Text PDFRegulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to organotypic hippocampal slice culture.
F1000Res
January 2025
Faculty of Teaching and Education Sciences, Islamic University of Malang, Malang, East Java, Indonesia.
Background: Neurodegeneration due to neurotoxicity is one of the phenomena in temporal lobe epilepsy. Experimentally, hippocampal excitotoxicity process can occur due to kainic acid exposure, especially in the CA3 area. Neuronal death, astrocyte reactivity and increased calcium also occur in hippocampal excitotoxicity, but few studies have investigated immediate effect after kainic acid exposure.
View Article and Find Full Text PDFHealth-related quality of life of children and adolescents with one vs. multiple disabilities - Are there differences from the parents' perspective?
J Intellect Dev Disabil
March 2024
Faculty of Medicine, Department of Psychology, University of Novi Sad, Novi Sad, Republic of Serbia.
Background: Multiple disabilities represent separate entities that cannot be reduced to the sum of disabilities or the main disability. This study compared the health-related quality of life (HRQoL) of children and adolescents with multiple disabilities and those with one developmental disability. We further assessed how comorbidities and guardianship type affected HRQoL.
View Article and Find Full Text PDFDeterminants of Dropping Out of Remote Patient-Reported Outcome-Based Follow-Up Among Patients With Epilepsy: Prospective Cohort Study.
JMIR Form Res
January 2025
Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Background: The use of patient-reported outcome (PRO) measures is an emerging field in health care. In the Central Denmark Region, epilepsy outpatients can participate in remote PRO-based follow-up by completing a questionnaire at home instead of attending a traditional outpatient appointment. This approach aims to encourage patient engagement and is used in approximately half of all epilepsy outpatient consultations.
View Article and Find Full Text PDFTeaching Video NeuroImage: Rhythmic Ictal Nonclonic Hand Motions: A Valuable Lateralizing Sign in Focal Epilepsy.
Neurology
February 2025
Department of Neurology, Washington University School of Medicine, St. Louis, MO; and.
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