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A two-stage robust optimization model for emergency service facilities location-allocation problem under demand uncertainty and sustainable development.
Sci Rep
January 2025
School of Business Administration, Liaoning Technical University, Huludao, 125105, People's Republic of China.
Under the backdrop of frequent emergencies, the rational layout of emergency service facilities (ESF) and the effective allocation of emergency supplies have emerged as crucial in determining the timeliness of post-disaster response. By adequately accounting for potential uncertainties and carrying out comprehensive pre-planning, the robustness of location-allocation decisions can be significantly improved. This paper delves into the ESF network design problem under demand uncertainty and formulates this problem as a two-stage robust optimization model.
View Article and Find Full Text PDFAlthough the comparison between two great Victorian masterminds, Sigmund Freud and Sherlock Holmes, and their respective methods, is in itself not new (see for example Ginzburg 1979, 1980; Brooks 1984; Marcus 1984; Shephard 1985; Spence 1987), it merits further investigation, as it raises important questions regarding the nature and structure of clinical evidence, clinical epistemology, and clinical narration. In this article, the author: refers both to the common cultural background of these two projects (including the of the modern world and the complicated dialog between rationality and imagination) and their common epistemological situation; analyses their and , and characterizes both Holmes and Freud as and . Their operandi are described as hermeneutical procedures, methodologically similar to Charles Sanders Peirce's .
View Article and Find Full Text PDFIntegrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis.
Front Genet
January 2025
Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Objectives: Unlike other diseases, cancer is not just a genome disease but should broadly be viewed as a disease of the cellular machinery. Therefore, integrative multifaceted approaches are crucial to understanding the complex nature of cancer biology. Bcl-2 (B-cell lymphoma 2), encoded by the human BCL-2 gene, is an anti-apoptotic molecule that plays a key role in apoptosis and genetic variation of Bcl-2 proteins and is vital in disrupting the apoptotic machinery.
View Article and Find Full Text PDFNon-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs.
Sci Rep
January 2025
Physical Plasma Medicine Laboratories, Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.
Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS).
View Article and Find Full Text PDF12-Hydroxy-Lauric Acid Tethered Self-Assembled Heterochiral Diphenylalanine-Based Mechanoresponsive and Proteolytically Stable Hydrogel: A Dual Player for Handling Cancer and Bacterial Challenges.
ACS Appl Bio Mater
January 2025
Department of Applied Chemistry, Rajiv Gandhi Technological University, Bhopal 462033, Madhya Pradesh, India.
Deciphering the most promising strategy for the evolution of cancer patient management remains a multifaceted, challenging affair to date. Additionally, such approaches often lead to microbial infections as side effects, probably due to the compromised immunity of the patients undergoing such treatment. Distinctly, this work delineates a rational combinatorial strategy harnessing stereogenic harmony in the diphenylalanine fragment, tethering it to an amphiphile 12-hydroxy-lauric acid at the N-terminus (compounds -) such that a potential therapeutic could be extracted out from the series.
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