AI Article Synopsis
- Recent studies show that methylation in the hepatitis B virus (HBV) genome could play a role in controlling how the virus replicates and is transcribed.
- The connection between this methylation and occult hepatitis is still uncertain.
- Research found specific CpG sites in the HBV genome that are often hypermethylated in liver cancer patients, but not in those with chronic hepatitis.
Article Abstract
Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.
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| http://dx.doi.org/10.1086/655398 | DOI Listing |
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