Chromosomal abnormalities in women with premature ovarian failure.

Gynecol Endocrinol

Division of Obstetrics and Gynecology, Department of Reproductive Medicine and Child Development, University of Pisa, Via Roma 56, 56126 Pisa, Italy.

Published: October 2010

AI Article Synopsis

  • Premature ovarian failure involves the early loss of ovarian function, distinct from early menopause as some patients can still ovulate and even become pregnant.
  • The causes and mechanisms behind premature ovarian failure are still debated, but genetics are widely acknowledged as significant contributors.
  • This review aims to highlight known inherited factors related to the condition, assisting healthcare providers in counseling affected women who may become pregnant.

Article Abstract

Premature ovarian failure is a complex disorder that results in the early loss of ovarian function; however this disease must be separated from early menopause because these patients can sporadically ovulate and in literature are described pregnancies. The aetiology and the patho-physiology of premature ovarian failure are still matter of debate, but is commonly accepted that genetic factors play an important role. This review is aimed to present an overview of known inherited factor implied in the pathogenesis of this disorder to help physician in the counselling of affected pregnant women.

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Source
http://dx.doi.org/10.3109/09513590.2010.500427DOI Listing

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