Treatment of keloid remains a great challenge for clinicians, in spite of numerous therapeutic regimens reported in the literature to date. Earlobe or postauricular regions are predominant locations for postoperative keloids due to the treatment of lop ears. There are several treatments that include intralesional steroid injections, surgical excision, cryotherapy, laser therapy, radiotherapy and pharmacotherapy. A case is presented with fourth recurrence of keloids after surgical treatment of lop ears with final satisfactory outcome after combined therapy that included surgical excision, skin flap transposition and radiotherapy. It is concluded that interdisciplinary approach that includes a combination of surgery and radiotherapy results in a satisfactory outcome of keloid treatment.
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Antioxidants (Basel)
December 2024
Department of Biomaterials Science (BK 21 FOUR Program), Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Oxidative stress is the key cause of the etiopathogenesis of several diseases associated with constipation. This study examined whether the green pine cone can improve the symptoms of constipation based on the antioxidant activities. The changes in the key parameters for the antioxidant activity and laxative effects were examined in the loperamide (Lop)-induced constipation of Sprague-Dawley (SD) rats after being treated with the methanol extracts of green pine cone (MPC, unripe fruits of ).
View Article and Find Full Text PDFCureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences Bibinagar, Hyderabad, IND.
Pre-sternal keloids are a distinct clinicopathological entity differing in many ways from keloids occurring elsewhere, as there are differences in pathogenesis, clinical presentation, and management. We have reviewed commonly used assessment scales like the Vancouver Scar Scale, the Patient and Observer Scar Assessment Scale, and the Detroit Keloid Scale and identified some shortcomings in applying them in assessing pre-sternal keloids. Therefore, we developed the AIIMS Bhopal pre-sternal keloid scale (ABPSKS), a pre-sternal keloid-specific tool to enable the assessment of the severity of the disease, the efficacy of treatment, and the comparison of outcomes of different treatment modalities.
View Article and Find Full Text PDFFront Oncol
December 2024
Clinic for Otorhinolaryngology, University Hospital Leipzig, Leipzig, Germany.
Introduction: The larynx organ preservation (LOP) trial DeLOS-II enrolled = 173 patients with advanced laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) amenable (only curatively resectable) through total laryngectomy (TL) to receive induction chemotherapy (IC) with TPF [docetaxel (T), cisplatin (P), and 5-fluorouracil (F)] (arm A, 85 patients) or additional cetuximab (E) weekly (arm B, 88 patients). Responders with endoscopic estimated tumor surface shrinkage (ETSS) ≥30% after 1 cycle IC (IC-1) received a further two cycles of IC followed by radiotherapy (RT), whereas TL was recommended for non-responders. Arm B failed to show superior 24-month laryngectomy-free survival (LFS) and overall survival (OS), the protocol-specified primary and secondary endpoints.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
: Sinonasal mucosal melanoma (SNMM) is a rare and aggressive melanoma subtype with a notably poor prognosis compared to cutaneous melanoma (CM). Despite advances in molecular characterization, SNMM remains underexplored, posing a clinical challenge and highlighting the need for detailed molecular profiling. This study aimed to identify the molecular features of SNMM, elucidate its clinical behavior and prognostic implications, and provide insights for improved therapeutic strategies.
View Article and Find Full Text PDFBehav Brain Res
March 2025
Center of Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil. Electronic address:
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