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Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies.
Oncogene
January 2025
Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second Hospital, State Key Laboratory of Biotherapy, and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P. R. China.
Genome-wide functional genetic screening has been widely used in the biomedicine field, which makes it possible to find a needle in a haystack at the genetic level. In cancer research, gene mutations are closely related to tumor development, metastasis, and recurrence, and the use of state-of-the-art powerful screening technologies, such as clustered regularly interspaced short palindromic repeat (CRISPR), to search for the most critical genes or coding products provides us with a new possibility to further refine the cancer mapping and provide new possibilities for the treatment of cancer patients. The use of CRISPR screening for the most critical genes or coding products has further refined the cancer atlas and provided new possibilities for the treatment of cancer patients.
View Article and Find Full Text PDFAlthough the comparison between two great Victorian masterminds, Sigmund Freud and Sherlock Holmes, and their respective methods, is in itself not new (see for example Ginzburg 1979, 1980; Brooks 1984; Marcus 1984; Shephard 1985; Spence 1987), it merits further investigation, as it raises important questions regarding the nature and structure of clinical evidence, clinical epistemology, and clinical narration. In this article, the author: refers both to the common cultural background of these two projects (including the of the modern world and the complicated dialog between rationality and imagination) and their common epistemological situation; analyses their and , and characterizes both Holmes and Freud as and . Their operandi are described as hermeneutical procedures, methodologically similar to Charles Sanders Peirce's .
View Article and Find Full Text PDFMultimodal multiobjective optimization with structural network control principles to optimize personalized drug targets for drug discovery of individual patients.
Brief Bioinform
November 2024
School of Electrical and Information Engineering, Zhengzhou University, No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province, China.
Structural network control principles provided novel and efficient clues for the optimization of personalized drug targets (PDTs) related to state transitions of individual patients. However, most existing methods focus on one subnetwork or module as drug targets through the identification of the minimal set of driver nodes and ignore the state transition capabilities of other modules with different configurations of drug targets [i.e.
View Article and Find Full Text PDF'Sneaky' uninflamed oesophageal candidiasis: morphological clues and comparison with candidiasis associated with inflammation.
J Clin Pathol
January 2025
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Article Synopsis
- The study aimed to investigate the relationship between the histological characteristics of esophageal candidiasis and various clinical factors, highlighting instances where inflammation might not be present.
- A review of 53 biopsy specimens revealed that acute inflammation was absent in about 38% of cases, and smoking significantly correlated with this absence of inflammation.
- Findings suggest that smokers may experience a unique immunosuppressive effect in relation to esophagitis, as the inflammation was often missing in their biopsies compared to non-smokers.
Identification of apoptosisrelated long noncoding RNAs expression profiles in patient with cervical intraepithelial neoplasia 3.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
Objectives: Long non-coding RNAs (lncRNAs) play an essential role in cancer biology. Cervical intraepithelial neoplasia grade 3 (CIN3) is the most severe precancerous lesion of cervical cancer. However, the mechanism of multiple lncRNAs in CIN3 has not been studied in-depth and is worth exploring.
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