Background: Hepatitis C virus (HCV) vertical transmission is considered the main route of HCV infection in children. Some authors have stated that cesarean section (C/S) can reduce perinatal HCV transmission. However, the study findings are heterogeneous and high-quality studies are lacking.
Aims: To evaluate the effect of mode of delivery on the risk of perinatal mother-to-infant transmission of HCV.
Methods: Only the peer-reviewed published studies that compared perinatal transmission rate of HCV in elective or emergency cesarean section with vaginal delivery in HCV-RNA+/HIV- mothers were included. We applied the random effect model of DerSimonian and Laird method with heterogeneity and sensitivity analyses.
Results: We identified 8 studies that involved 641 unique mother-infant pairs which fulfilled our inclusion criteria. Aggregation of study results did not show a significant decrease in HCV vertical transmission among study (mothers who underwent C/S) versus control (mothers who gave birth vaginally) patients [pooled odds ratio, 1.1 (95% CI 0.45-2.67)]. The P value was 0.35 for our test of heterogeneity.
Conclusions: Our meta-analysis suggests that C/S does not decrease perinatal HCV transmission from HCV-RNA+/HIV- mothers to infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00404-010-1588-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characteristics of Hepatitis B Virus, Hepatitis C Virus, and Syphilis Coinfection in People With HIV/AIDS Contracted Through Different Sources: Retrospective Study.
JMIR Public Health Surveill
February 2024
Zhongnan Hospital of Wuhan University, Wuhan, China.
Background: The burden of hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis coinfections remains disproportionately high among people living with HIV/AIDS. Hubei province is located in central China, where there are distinct regional characteristics of the distribution of people living with HIV/AIDS acquired via diverse transmission routes and the AIDS epidemic itself.
Objective: We aimed to estimate the magnitude of HBV, HCV, or syphilis coinfections among people living with HIV/AIDS with blood-borne transmission, which includes former paid blood donors, contaminated blood recipients, and intravenous drug users, as well as among people with sex-borne HIV transmission (including heterosexual people and men who have sex with men) and people with mother-to-child HIV transmission.
Maternal neighbourhood-level social determinants of health and their association with paediatric hepatitis C screening among children exposed to hepatitis C in pregnancy.
Paediatr Perinat Epidemiol
February 2024
Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Article Synopsis
- Current guidelines suggest that children exposed to HCV in utero should be screened by 18 months of age, but only a small percentage actually receive this screening in Canada.
- A study analyzed data from children born between 2000 and 2016 to mothers with HCV, discovering that only 29% were screened by age two and highlighting significant maternal social determinants of health such as income and neighborhood stability.
- The findings indicate that factors like rural living and residing in high-dependency areas are linked to lower screening rates, while younger maternal age, HIV co-infection, and specialist involvement are associated with higher screening rates.
Timing of Positive Hepatitis C Virus Test Results During and 1 Year Before Pregnancy.
Obstet Gynecol
December 2022
Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, and the Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia; Eagle Global Scientific, LLC, San Antonio, Texas; the Tennessee Department of Health, Nashville, Tennessee; the Pennsylvania Department of Health, Pittsburgh, Pennsylvania; and the New York State Department of Health, Albany, and the New York City Department of Health and Mental Hygiene, New York, New York.
Article Synopsis
- - The incidence of hepatitis C virus (HCV) infections has increased significantly in reproductive-aged adults over the past decade, posing risks for both maternal health and perinatal transmission.
- - Despite the availability of effective curative treatments for HCV, these are not recommended during pregnancy, raising concerns about missed opportunities for timely intervention.
- - A study across four U.S. jurisdictions found that among 1,161 pregnancies from 2018-2021 involving individuals with HCV, a notable percentage had their first HCV detection before pregnancy, suggesting gaps in treatment that could have benefited maternal health and reduced transmission risks.
Universal versus targeted screening for HCV infection in pregnancy in a diverse, multi-ethnic population: Universal screening is more comprehensive.
J Viral Hepat
December 2022
Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.
Universal hepatitis C screening in pregnancy is not recommended by NICE due to a lack of effective interventions to prevent mother to child transmission (MTCT) and is only offered to pregnant women at increased risk of infection (intra-venous drug use [IVDU] or with a HCV positive family member). No testing is offered to patients from high endemic areas. However, data regarding true seroprevalence in multi-ethnic inner-city populations in the UK are required.
View Article and Find Full Text PDFHepatitis C viral load and mother-to-child transmission: A systematic review and meta-analysis.
J Gastroenterol Hepatol
February 2023
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Background And Aim: We aim to assess the association between maternal hepatitis C virus (HCV) viral load and human immunodeficiency virus (HIV) coinfection and the risk for mother-to-child transmission (MTCT) among pregnant women infected with HCV.
Methods: A literature search of the Medline, Embase, Central, Science Citation Index Expanded (SCIE), Conference Proceedings Citation Index-Science (CPCIS), Scopus, Literature Latino-Americana e do Caribe em Ciências da Saúde (LILACS), and WHO Global Index Medicus databases, from inception to June 21, 2022, was performed. Studies that reported the incidence HCV-MTCT were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!