AI Article Synopsis
- The study aimed to determine whether a specific genetic variation in the alpha(2B)-adrenergic receptor gene is linked to migraine susceptibility in a Chinese Han population.
- A case-control approach involved comparing 368 migraine patients with 517 healthy controls, using DNA analysis to investigate the polymorphism.
- The results indicated no significant association between the genetic variation and migraine risk, suggesting the polymorphism may not play a functional role in this condition.
Article Abstract
Objective: The present study aimed to estimate the association between susceptibility to migraine and the 12-nucleotide insertion/deletion (indel) polymorphism in promoter region of alpha(2B)-adrenergic receptor gene (ADRA2B).
Methods: A case-control study was carried out in Chinese Han population, including 368 cases of migraine and 517 controls. Genomic DNA was extracted from blood samples, and DNA fragments containing the site of polymorphism were amplified by PCR. Data were adjusted for sex, age, migraine history and family history, and analyzed using a logistic regression model.
Results: There was no association between indel polymorphism and migraine, at either the allele or the genotype level.
Conclusion: These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552571 | PMC |
| http://dx.doi.org/10.1007/s12264-010-0301-0 | DOI Listing |
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