Objective: To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.
Methods: PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.
Results: PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).
Conclusion: Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.
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