AI Article Synopsis
- The study aimed to evaluate the expression levels of human beta-defensins 1 and 2 (hBD-1 and hBD-2) in nasal tissue before and after endoscopic sinus surgery in chronic sinusitis patients.
- Samples were collected at various time points post-surgery to measure hBD levels and categorize patient responses as cured, responsive, or non-responsive.
- Findings revealed that hBD-2 levels increased significantly in patients who responded well to surgery, indicating its potential use as a prognosis indicator, while hBD-1 showed less correlation with patient outcomes.
Article Abstract
Objective: To observe the expressions of human beta-defensin 1 and 2 (hBD-1 and hBD-2) in nasal mucosa before and after the endoscopic sinus surgery and investigate the effects of hBD-1 and hBD-2 on the healing process after the surgery.
Methods: The patients undergoing endoscopic sinus surgery for chronic sinusitis were divided into 3 groups according to the response to the surgery, namely cured group, response group and non-response group. With those from healthy control subjects as the control, nasal mucosa samples were collected from the patients at 1 week, 2 weeks, 1 month, 3 months and 6 months after the surgery for detection of hBD-1 and hBD-2 mRNA and protein expressions by RT-PCR and Western blotting.
Results: hBD-1 and hBD-2 were expressed in both normal and chronic sinusitis mucosa, but the expression levels varied significantly between the individuals. The expression levels of hBD-2 was significantly correlated to the patients' response to the surgical treatment (P<0.05). hBD-1 showed slight differences between the individuals, but was not associated with the patients' prognosis.
Conclusion: The expressions of hBD-2 mRNA and protein are significantly increased in patients with good response to endoscopic sinus surgery for chronic sinusitis, suggesting the value of hBD-2 as an indicator of the patients' prognosis.
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