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Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation. | LitMetric

Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation.

Ultrason Sonochem

College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, PR China.

Published: January 2011

AI Article Synopsis

Article Abstract

Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.

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Source
http://dx.doi.org/10.1016/j.ultsonch.2010.05.010DOI Listing

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