Two triterpenes, beta-amyrin and 12-oleanene 3beta, 21beta-diol, were isolated as a mixture from the chloroform soluble fraction of an ethanol extract of Duranta repens Linn (Verbenaceae) stem. The structures of the two compounds were confirmed by analysis of their IR, (1)H-NMR, (13)C-NMR and LC-MS spectral data. The mixture of beta-amyrin and 12-oleanene 3beta, 21beta-diol (compound 1) was highly effective against the larvae of the mosquito, Culex quinquefasciatus Say (Diptera: Culicidae), as a mosquitocide.
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http://dx.doi.org/10.3109/13880200903096570 | DOI Listing |
Access Microbiol
October 2022
Bacterial Genomics and Evolution Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.
is a highly evolved group of phytopathogenic bacteria infecting nearly 400 host plants having vast genomic resources available with heterogenicity in representation from different species and pathovars. Unfortunately, the wealth of data is extremely biased and restricted to a few pathogens that infect economically important plants, while those reported to infect the most diverse plants remain neglected. In the present study, we report the first complete genome sequence of pv.
View Article and Find Full Text PDFJ Diabetes Metab Disord
June 2022
Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010 India.
Background: Type-2 diabetes mellitus is a common metabolic disorder characterized by insulin resistance, a relative impairment in insulin secretion, and a certain degree of genetic predisposition. The rapid rise in the prevalence of diabetes mellitus around the world has assisted in the development of new pharmacologically active compounds. The current study was aimed to investigate and validate the anti-diabetic activity of wild-grown plant L.
View Article and Find Full Text PDFAppl Biochem Biotechnol
June 2022
Department of Zoology for UG and PG Studies, Serampore College (Under the University of Calcutta), Serampore, West Bengal, India.
Warm and humid climate creates ideal conditions for mosquito breeding. The ability of these vectors to spread a number of diseases to humans causes millions of deaths every year. Indiscriminate use of synthetic insecticides leads to the development of resistance in vector mosquitoes and along with this, these pesticides cause biological magnification of toxic components and affects adversely the non-target organisms including human being.
View Article and Find Full Text PDFJ Diabetes Metab Disord
December 2020
Department of Pharmacology and Toxicology, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010 India.
Background: Although α-amylase is the choice of target to manage postprandial hyperglycemia, inhibitors of this enzyme may get absorbed into the systemic circulation and modulate proteins involved in the pathogenesis of diabetes mellitus. Hence, the present study aimed to identify α-amylase inhibitors from via and and predict their role in the modulation of multiple pathways involved in diabetes mellitus.
Methods: α-amylase inhibitory activity of hydroalcoholic extract/fractions (s) and pure compounds from was performed using enzyme inhibitory assay.
J Integr Med
January 2021
Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India. Electronic address:
Objective: Duranta repens is reported to contain a wide array of secondary metabolites, including α-amylase and α-glucosidase inhibitors, and - has potent antioxidant activity. The present study evaluated the network pharmacology of D. repens (whole plant) with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of D.
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