AI Article Synopsis
- Guava budding leaf extract (PE) has demonstrated significant bioactivities, particularly linked to its content of polyphenolic compounds.
- The study identified seven major compounds in PE, including gallic acid and quercetin, which contribute to its effectiveness against glycation in low-density lipoprotein (LDL) mimics.
- Findings suggest that PE’s antiglycative effects follow a dose-dependent inhibition model and present distinct kinetic patterns across four phases.
Article Abstract
Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.
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| http://dx.doi.org/10.3109/13880200903029365 | DOI Listing |
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