Nanocarriers with multilayer core-shell architecture were prepared by coating a superparamagnetic Fe(3)O(4) core with a triblock copolymer. The first block of the copolymer formed the biocompatible outermost shell of the nanocarrier. The second block that contains amino groups and hydrophobic moiety formed the inner shell. The third block bound tightly onto the Fe(3)O(4) core. Chlorambucil (an anticancer agent) and indomethacin (an anti-inflammation agent), each containing a carboxyl group and a hydrophobic moiety, were loaded into the amino-group-containing inner shell by a combination of ionic and hydrophobic interactions. The release rate of the loaded drugs was slow at pH 7.4, mimicking the blood environment, whereas the release rate increased significantly at acidic pH, mimicking the intracellular conditions in the endosome/lysosome. This can be attributed to the disruption of the ionic bond caused by protonation of the carboxylate anion of the drugs and the swelling of the inner shell caused by protonation of the amino groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b9nr00244h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer.
Bioengineering (Basel)
December 2024
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94115, USA.
In exploring adjuvant therapies for head and neck cancer, hyperthermia (40-45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study investigates the feasibility of delivering targeted uniform hyperthermia deep into the tissue using a non-invasive ultrasound spherical random phased array transducer.
View Article and Find Full Text PDFExploration of biomass-derived carbon dots based on chestnut shell for the sensitive detection of phosphate and tetracycline hydrochloride.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
Phosphate pollution leads to the deterioration of water quality, posing a serious threat to human health. Tetracycline hydrochloride (TC), a class of broad-spectrum bacteriostatic agents, has garnered attention due to its extensive use and potential toxicity. Therefore, developing a highly selective and sensitive fluorescent probe for the detection of phosphates and TC is of significant importance.
View Article and Find Full Text PDFIntraprosthetic Dislocation Following Dual Mobility Total Hip Arthroplasty: A Retrieval Analysis Study.
Arthroplast Today
February 2025
Department of Orthopaedic Surgery, Fiona Stanley Fremantle Hospitals Group, Murdoch, Western Australia, Australia.
Background: Dual mobility (DM) implants in total hip arthroplasty provide excellent range of motion with low dislocation rates. A complication of this design is intraprosthetic dislocation (IPD), where the polyethylene (PE) liner dissociates from the femoral head. In older designs, IPD occurred due to a small head size and late PE wear with head-capture-mechanism failure.
View Article and Find Full Text PDFContinuous-flow phosphate removal using Cry-Ca-COS Monolith: Insights from dynamic adsorption modeling.
Water Res X
May 2025
Integrated Science and Technology Research Center, Faculty of Technology and Environment, Prince of Songkla University, Phuket Campus, Kathu, Phuket 83120 Thailand.
This study rigorously evaluates the adsorption performance of the Cry-Ca-COS monolith for phosphate removal in a column operation mode. Characterization of the material both before and after exhaustion in a continuous flow system (column form) showed no difference compared to results from a batch system (tablet form). The XPS results indicated that the adsorption mechanism of phosphate on the Cry-Ca-COS column involved surface microprecipitation and ligand exchange (inner-sphere complexation).
View Article and Find Full Text PDFPhosphorus Oxidation Controls Epitaxial Shell Growth in InP/ZnSe Quantum Dots.
ACS Nano
January 2025
Optoelectronic Materials Section, Faculty of Applied Sciences, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
InP/ZnSe/ZnS core/shell/shell quantum dots are the most investigated quantum dot material for commercial applications involving visible light emission. The inner InP/ZnSe interface is complex since it is not charge balanced, and the InP surface is prone to oxidation. The role of oxidative defects at this interface has remained a topic of debate, with conflicting reports of both detrimental and beneficial effects on the quantum dot properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!