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Monkeypox is a rare zoonotic infection caused by monkeypox virus. It is an emerging disease which has become the most prevalent orthopoxvirus since the global eradication of smallpox in 1980. It is a mild illness which is mostly characterized by a prodromal of fever, malaise and progressive appearance of vesiculo-papular skin lesions.

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Background: Kawasaki disease (KD) is a medium and small vessel vasculitis which usually has a good response to immunoglobulin therapy (IVIG). We present a case of incomplete KD with IVIG resistance associated with an unusual combination of vesicular guttate-psoriasiform rash, hypertension and late onset small joint arthritis.

Case Presentation: A four-month-old male infant from Sri Lanka presented with high fever, conjunctival redness, pedal oedema and skin rash.

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Acantholytic dyskeratosis mimicking Grover disease as a cutaneous manifestation of a side effect to the Moderna (mRNA-1273) COVID vaccine is rare with only one documented case in the literature to date. Herein, we present a case of an eruptive, erythematous, vesiculopapular rash developing in a patient after the Moderna vaccine. Histopathology of a representative biopsy [x2, done 8 weeks apart] of the rash revealed similar histopathologic findings of patchy suprabasal acantholysis with dyskeratotic keratinocytes and an underlying inflammatory infiltrate of lymphocytes and neutrophils.

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Article Synopsis
  • Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) causes skin eruptions, often in sun-exposed areas, and can occasionally affect the eyes.
  • A 7-year-old boy with HVLPD had eye symptoms for over 2 years, leading to anterior uveitis and corneal nebulae, though he didn't experience vision loss.
  • Recognizing potential eye complications in HVLPD patients is essential to avoid severe outcomes.
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Cutaneous manifestations are considered an infrequent presentation of coronavirus disease 2019 (COVID-19) and are mostly described in outpatient settings. Its onset during the course of the severe COVID-19 disease has been poorly described in severe cases. Studies focused on dermatological manifestations mostly described maculopapular or pernio-like lesions and less frequently vesicular or varicella-like eruption.

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