This article describes considerations in health and behavioral sciences small grant management and describes lessons learned during post-award implementation. Using the components by W. Sahlman [Sahlman, W. (1997). How to write a great business plan. Harvard Business Review, 75(4), 98-108] as a business framework, a plan was developed that included (a) building relationships with people in the research program and with external parties providing key resources, (b) establishing a perspective of opportunity for research advancement, (c) identifying the larger context of scientific culture and regulatory environment, and (d) anticipating problems with a flexible response and rewarding teamwork. Small grant management included developing a day-to-day system, building a grant/study program development plan, and initiating a marketing plan.
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http://dx.doi.org/10.1016/j.apnr.2008.06.006 | DOI Listing |
Small
March 2025
College of Materials Science and Engineering, Fuzhou University, New Campus, Minhou, Fujian, 350108, China.
Overcoming the challenges of integrating disparate components in nanoarchitectures, this study introduces a straightforward strategy based on a mixed-valence coordination approach, creating an ordered ternary heterostructure integrated with ultrasmall homojunction. This singular ordered homojunction-heterostructure unites ultrathin 1D rutile TiO nanowires (NWs) and ultrathin anatase TiO NWs with 0D Prussian Blue Analogs (PBAs) nanoparticles (NPs), all exhibiting crystallographic oriented alignment with each other, forming a ternary mesocrystals. Experimental and theoretical insights disclose that the complex interplay between these dissimilar components is governed by a spontaneous lattice match effect, which not only optimizes but also directs the charge transfer, thereby enhancing both efficiency and stability.
View Article and Find Full Text PDFBackground: In vitro oocyte maturation (IVM) is not a novel concept; however, its wide-scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Methods: This comprehensive review addresses the significant advances made in oocyte in vitro maturation with the biphasic capacitation (CAPA)-IVM strategy applied to small ovarian antral follicles in humans over the last 10 years. CAPA-IVM consists of a prematuration phase wherein immature oocytes are temporarily meiotically arrested to gain competence before undergoing meiotic resumption.
Nutrients
February 2025
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.
Background/objectives: High fiber (34-36 g/day) diets are recommended during pregnancy due to inverse associations with constipation and adverse pregnancy health outcomes, including pre-eclampsia and gestational diabetes. However, the mechanism for this protective effect is poorly defined. Fiber may be protective due to its impact on the composition and function of specific bacteria within the pregnancy gut microbiome.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.
Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous group of malignancies with poor survival outcomes, particularly in advanced stages. Identifying prognostic biomarkers could help improve patient management. miR-375, a small non-coding RNA, has been shown to influence tumor growth and immune responses, making it a candidate biomarker.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
MiRNAs regulate follicle development and atresia, steroid production, granulosa cell (GC) proliferation, and apoptosis. However, the target genes and the functioning of novel miRNAs remain unexplored. We reveal the targeting relationship between novel-m0297-5p and and the specific regulatory mechanism of GC proliferation in small-tailed Han sheep using whole transcriptomic sequencing.
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