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Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange.
Metab Brain Dis
June 2013
Department of Hepatology, A-2121, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Severe liver injury result in development of hepatic encephalopathy (HE) and often also in brain edema that is a potentially fatal complication. HE and brain edema are correlated to the level and persistence of hyperammonemia and the presence of systemic inflammation. Treatment of HE and brain edema is based on restoring and keeping normal physiological variables including tonicity, blood gasses, lactate, temperature and vascular resistance by a wide variety of interventions.
View Article and Find Full Text PDFInfluence of cell culture configuration on the post-cryopreservation viability of primary rat hepatocytes.
Biomaterials
January 2012
Low Temperature Preservation Unit, National University Medical Institutes Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Cryopreservation has been identified as a necessary barrier to overcome in the production of tissue engineered products for clinical application. Liver engineering and bioartificial liver assisting devices are on the forefront of tissue engineering research due to its high demand and clinical potential. In this study we propose that the cryopreservation of primary mammalian hepatocytes yields better results when these cells are in a tissue-like culture configuration since cell attachment is essential for cell survival in this cell type.
View Article and Find Full Text PDFAcute liver failure.
Curr Opin Crit Care
April 2011
Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Purpose Of Review: Acute liver failure (ALF) results in a multitude of serious complications that often lead to multi-organ failure. This brief review focuses on the pathophysiological processes in ALF and how to manage these.
Recent Findings: The clinical presentation in ALF ranges from slightly altered conscious level with profound coagulopathy to coma with a catastrophic failure of multiple organs, including uncontrollable cerebral edema and brain death, which is rarely seen in decompensated cirrhosis.
Survival predictors in patients treated with a molecular adsorbent recirculating system.
World J Gastroenterol
June 2009
Department of Anesthesiology and Intensive Care Medicine, Surgical Hospital of Helsinki, Helsinki University Central Hospital, HUCH, Helsinki, Finland.
Aim: To identify prognostic factors for survival in patients with liver failure treated with a molecular adsorbent recirculating system (MARS).
Methods: MARS is a liver-assisting device that has been used in the treatment of liver failure to enable native liver recovery, and as a bridge to liver transplantation (LTX). We analyzed the 1-year outcomes of 188 patients treated with MARS, from 2001 to 2007, in an intensive care unit specializing in liver disease.
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